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Thank you!

I wanted to comment on this: " The vast majority of studies making it into the meta-study are from the 1980s, 1990s and early 2000s. Back then transgender medicine was much more ‘medicalist’ in that any intervention required a lot of preceding psychotherapy and assessment was much more rigorous. "

In fact, the outcome studies from these periods are not conclusive in showing benefit or lack of regret either.

The paper cited, Bustos et al., 2021, had a letter to the editor and an appendix of another paper which both note its numerous problems, making it unreliable (both open access: https://pmc.ncbi.nlm.nih.gov/articles/PMC8751779/ and https://link.springer.com/article/10.1007/s10508-023-02623-5 ). These studies often had huge loss to follow-up, often didn't follow up long enough (10 years seems to be the average surgical regret time) and had design problems. The Bustos et al review leans heavily on the Wiepjes et al 2018 paper which lost 36% of participants (who stopped coming in for lifelong treatment), as it was merely a record search and required the patient to ask to reverse hormones and to say they had regret (and to keep coming to the clinic, which served 95% of those in the Netherlands at the time). Wiepjes et al 2018 also noted that many patients had not been followed up the average 10 years to regret they'd seen.

Bustos et al even notes limitations:

"However, limitations such as significant heterogeneity among studies and among instruments used to assess regret rates, and moderate-to-high risk of bias in some studies represent a big barrier for generalization of the results of this study. The lack of validated questionnaires to evaluate regret in this population is a significant limiting factor. In addition, bias can occur because patients might restrain from expressing regrets due to fear of being judged by the interviewer. Moreover, the temporarity of the feeling of regret in some patients and the variable definition of regret may underestimate the real prevalence of “true” regret."

To be more precise, 23 of the 27 studies had moderate to high risk of bias ("some studies")--and only 174 of the thousands of patients were not in poor or fair quality studies.

An earlier review notes: (https://www.tandfonline.com/doi/abs/10.1080/10532528.2007.10559851 ) losses of followup ranging from "0% and 81%, with an average of 24%" for FTM and "between 0% and 73% did not participate in the follow-up, with an average attrition rate of 39%" for MTF as well as design problems ("the effects of SR were not always evaluated at the same point in the treatment process" for instance, "Furthermore, a number of investigators used only a posttest to measure the effects of SRS. In many studies, sound psychometric instruments were not used. "). These authors still claim " Despite methodological shortcomings of many of the studies, we conclude that SRS is an

effective treatment for transsexualism and the only treatment that has been

evaluated empirically with large clinical case series." (why???).

This is all to say that there is no reason to think that going back to their criteria would make the regret rate small (or more importantly, make very small the number of those who would not do it again knowing what they know now). I think we don't know the regret rate, not even for the past groups.

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